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Megan Coyle, Ph.D. prepares, files and prosecutes patent applications in the pharmaceutical and biotechnology industries. She also conducts searches and reviews due diligence, patentability and freedom-to-operate analyses.

Prior to becoming a patent agent, Megan was a postdoctoral researcher at the University of Pennsylvania where she studied the role of immune pathways in the progression of metabolic disease and identified type I Interferon signaling as an early response to high-fat diet feeding that contributes to weight gain and insulin resistance.

Megan’s doctoral research focused on understanding gene regulation in adipose tissue and transcriptional mechanisms for controlling energy expenditure. Megan’s work identified a novel mechanism by which a transcription factor blocks an immune pathway to promote mitochondrial function adipose tissue.

She has authored several research articles in journals including EMBO Journal and Proceedings of the National Academy of Sciences.

Megan is licensed to practice patent law exclusively before the United States Patent and Trademark Office (USPTO), and represents both foreign and domestic clients before the USPTO in the area of patent prosecution. Megan is not licensed to practice before state and federal court.
 
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  • Kissig M, Ishibashi J, Harms MJ, Lim HW, Stine RR, Won KJ, Seale P (2017) PRDM16 represses the type I Interferon response in adipocytes to promote mitochondrial and thermogenic programing. EMBO J 36:1528-1542. PMID: 28408438
  • Soccio RE, LZ, Chen ER, Foong YH, Benson KK, Dispirito JR, Mullican SE, Emmett MJ, Briggs ER, Peed LC, Dzeng RK, Medina CJ, Jolivert JF, Kissig M, Rajapurkar SR et al. (2017) Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice. J Clin Invest 127:1451-1462. PMID: 28240605
  • Kissig M, Shapira SN, Seale P (2016) SnapShot: Brown and Beige Adipose Thermogenesis. Cell 166:258-258. PMID: 27368105
  • Tran CM, Mukherjee S, Ye L, Frederick DW, Kissig M, Davis JG, Lamming DW, Seale P, Baur JA (2016) Rapamycin blocks induction of the thermogenic program in white adipose tissue. Diabetes 65:925-41. PMID: 27368105
  • Wang W, Kissig M, Rajakumari S, Huang L, Lim HW, Won KJ, Seale P (2014) Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proc Natl Acad Sci 111:14466-71. PMID: 25197048
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