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Sara Sims, Ph.D. prepares, files and prosecutes patent applications as well as conducts searches and reviews for due diligence, patentability and freedom-to-operate analyses within the pharmaceutical and biotechnical industries. She also provides technical and scientific support for both U.S. and foreign patent protection.

Before becoming a patent agent, Sara conducted four years of postdoctoral research in the Genetics Department at Harvard University, where she received a Ruth L. Kirschstein Postdoctoral Fellowship from the National Institutes of Health. While in her postdoc, Sara used combined genetic, molecular biology, biochemical and cytological approaches to assess the role of histone-modifying enzymes in promoting accurate meiotic cell division in C. elegans and to shed light on the transgenerational inheritance of epigenetic information.

As a graduate student, she worked in a yeast genetics lab, characterizing the function and regulation of a pair of novel proteins, Rgc1/2 (Regulators of the Fps1 Glycerol Channel), that play an unusual role in cell wall integrity. Her work demonstrated that these proteins may serve as effective antifungal drug targets.

During her undergraduate studies, Sara worked as a research assistant in a lab studying transcription regulation in E. coli.

Sara is licensed to practice patent law exclusively before the United States Patent and Trademark Office (USPTO), and represents both foreign and domestic clients before the USPTO in the area of patent prosecution. Sara is not licensed to practice before state and federal court.

Published In
  • Kim HM, Beese-Sims SE, Colaiacovo MP, “Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans,” Genetics. 2018 Jun;209(2):409-423.
  • Greer EL, Beese-Sims SE, Brookes E, Spadafora R, Zhu Y, Rothbart SB, Aristizabal-Corrales D, Chen S, Badeaux AI, Jin Q, Wang W, Strahl BD, Colaiacovo MP, and Shi Y, “A histone methylation network regulates transgenerational epigenetic memory in C. elegans,” Cell Rep. 2014 Apr 10;7(1):113-26.
  • Lee J, Reiter W, Dohnal I, Gregori C, Beese-Sims SE, Kuchler K, Ammerer G, Levin DE, “Hog1 MAPK closes the S. cerevisiae Fps1 glycerol channel by phosphorylating and displacing its positive regulators,” Genes Dev. 2013 Dec 1;27(23):2590-601.
  • Beese-Sims SE, Pan SJ, Lee J, Cormack BP, Levin DE, “Mutants in the Candida glabrata glycerol channels are sensitized to cell wall stress,” Euk Cell. 2012 Dec; 11(12):1512-9.
  • Beese-Sims SE, Lee J, Levin DE, “Yeast Fps1 glycerol facilitator functions as a homotetramer,” Yeast. 2011 Dec; 28(12):815-9.
  • Nottke AC, Beese-Sims SE, Pantalena LF, Reinke V, Shi Y, Colaiácovo MP, “SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair,” Proc Natl Acad Sci USA. 2011 Aug 2; 108(31):12805-10.
  • Beese SE, Negishi T, Levin DE, “Identification of positive regulators of the yeast fps1 glycerol channel,” PLoS Genet. 2009 Nov; 5(11):e1000738.
  • Jensen LT, Carroll MC, Hall MD, Harvey CJ, Beese SE, Culotta VC, “Down-regulation of a manganese transporter in the face of metal toxicity,” Mol Biol Cell. 2009 Jun; 20(12):2810-9.
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