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Tom Murray, Ph.D., is a patent agent in Ice Miller’s Intellectual Property Group.
 
Prior to joining Ice Miller, Tom was a patent agent at an intellectual property law firm in Washington, D.C. He has experience preparing and prosecuting patent applications; assisting in the formulation of invalidity, non-infringement, freedom-to-operate, clearance, and patentability opinions; and providing litigation document review support. In particular, Tom has patent prosecution experience in diverse technology areas such as microfluidics, antibody- and CAR T-cell-based therapeutics, cell culture methods, cell culture and processing devices, taste receptors and polymer chemistry.

Tom focused his Ph.D. studies at the University of California, Berkeley, on the design and development of microfluidic devices for investigating the structure and function of biological macromolecules involved in DNA replication initiation. Specifically, Tom designed and manufactured PDMS-based microdroplet microfluidic devices for use in biochemical assays. Additionally, he developed novel, high-transparency silicon nitride-based microfluidic devices for high-resolution molecular imaging experiments and collaborated with scientists at the Linac Coherent Light Source at Stanford (the world’s first hard X-ray free electron laser facility) and at Argonne National Laboratory for data collection. In addition to microfluidics and microfabrication, Tom’s doctoral research experience also included the construction and use of a single molecule microscope, fluorescence-based techniques (such as FRET), biochemistry, molecular biology and macromolecular structure determinations.

Prior to his graduate studies, Tom spent three years serving as a research technician for Professor Kathryn Ferguson in the Department of Physiology at the University of Pennsylvania. There, he studied the structure and function of the Epidermal Growth Factor Receptor (EGFR) family of receptor tyrosine kinases. He also refined his skills in molecular biology and gained experience in X-ray crystallography, biochemistry, protein expression (both bacterial and insect cell), and protein purification techniques.

Tom earned his Bachelor of Arts in biology, cum laude, with a concentration in molecular biology, from the University of Pennsylvania. During his studies, he conducted undergraduate research in the laboratory of Professor Erle Robertson in the Department of Virology. As an undergraduate research assistant, Tom gained experience in molecular biology and mammalian cell protein expression of viral proteins from the cancer-causing Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus.
 
Published In
  • Murray, T. D., Lyubimov, A. Y., Ogata, C. M., Vo, H., Uervirojnangkoorn, M., Brunger, A. T. and Berger, J. M. “A High-Transparency, Micro-Patternable Chip for X-Ray Diffraction Analysis of Microcrystals Under Native Growth Conditions,” Acta Crystallographica Section D, 2015, 71, 1987-1997
  • Lyubimov, A. Y., Murray, T. D., Koehl, A., Araci, I. E., Uervirojnangkoorn, M., Zeldin, O. B., Cohen, A. E., Soltis, S. M., Baxter, E. L., Brewster, A. S., Sauter, N. K., Brunger, A. T. and Berger, J. M. “Capture and X-ray Diffraction Studies of Protein Microcrystals in a Microfluidic Trap Array,” Acta Crystallographica Section D, 2015, 71, 928-940
  • Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O. B., Brewster, A.S., Murray, T.D., Sauter, N.K., Berger, J.M., Weis, W.I., and Brunger, A.T. “Integration Optimization, Triage and Analysis Tool for the Processing of XFEL Diffraction Images,” Journal of Applied Crystallography, 2016, 49, 1-8
Speaking Engagements
  • “Microfluidic Chips for Crystallography,” Biophysics Departmental Crystal Club meeting, Johns Hopkins University, September 2014
  • “Structural Studies of Clathrin’s Helical Linker,” Interdepartmental Crystal Talk meeting, University of Pennsylvania, February 2009
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